Publications

  1. Chakouri N, Rivas S, Roybal D, Yang L, Diaz J, Hsu AL, Mahling R, Chen B-X, Owoyemi JO, DiSilvestre D, Sirabella D, Corneo B, Tomaselli GF, Dick IE, Marx SO, Ben-Johny M. Fibroblast growth factor homologous factors serve as a molecular rheostat in tuning arrhythmogenic cardiac late sodium current. Nature Cardiovascular Research, 1, 491-503 (2022).

  2. Mahling R, Ben-Johny M. A bridge from the endoplasmic reticulum to the plasma membrane comes into view. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2202254119.

  3. Srinivasan L, Alzogaray V, Selvakumar D, Nathan S, Yoder JB, Wright KM, Klinke S, Nwafor JN, Labanda MS, Goldbaum FA, Schön A, Freire E, Tomaselli GF, Amzel LM, Ben-Johny M, Gabelli SB. Development of high-affinity nanobodies specific for NaV1.4 and NaV1.5 voltage-gated sodium channel isoforms. J Biol Chem. 2022 Apr;298(4):101763.

  4. Kschonsak M, Chua HC, Weidling C, Chakouri N, Noland CL, Schott K, Chang T, Tam C, Patel N, Arthur CP, Leitner A, Ben-Johny M, Ciferri C, Pless SA, Payandeh J. Structural architecture of the human NALCN channelosome. Nature. 2022 Mar;603(7899):180-186.

  5. Rivas S, Hanif K, Chakouri N, Ben-Johny M. Probing ion channel macromolecular interactions using fluorescence resonance energy transfer. Methods Enzymol. 2021;653:319-347

  6. Kang PW, Chakouri N, Diaz J, Tomaselli GF, Yue DT, Ben-Johny M. Elementary mechanisms of calmodulin regulation of NaV1.5 producing divergent arrhythmogenic phenotypes. Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2025085118.

  7. Sang L, Vieira DCO, Yue DT, Ben-Johny M, Dick IE. The molecular basis of the inhibition of CaV1 calcium-dependent inactivation by the distal carboxy tail. J Biol Chem. 2021 Jan-Jun;296:100502.

  8. Nathan S, Gabelli SB, Yoder JB, Srinivasan L, Aldrich RW, Tomaselli GF, Ben-Johny M, Amzel LM. Structural basis of cytoplasmic NaV1.5 and NaV1.4 regulation. J Gen Physiol. 2021 Jan 4;153(1):e202012722.

  9. Del Rivero Morfin PJ, Ben-Johny M. Cutting out the fat: Site-specific deacylation of an ion channel. J Biol Chem. 2020 Dec 4;295(49):16497-16498.

  10. Papa A, Kushner J, Hennessey JA, Katchman AN, Zakharov SI, Chen BX, Yang L, Lu R, Leong S, Diaz J, Liu G, Roybal D, Liao X, Del Rivero Morfin PJ, Colecraft HM, Pitt GS, Clarke O, Topkara V, Ben-Johny M, Marx SO. Adrenergic CaV1.2 Activation via Rad Phosphorylation Converges at α1C I-II Loop. Circ Res. 2021 Jan 8;128(1):76-88.

  11. Abrams J, Roybal D, Chakouri N, Katchman AN, Weinberg R, Yang L, Chen BX, Zakharov SI, Hennessey JA, Avula UMR, Diaz J, Wang C, Wan EY, Pitt GS, Ben-Johny M, Marx SO. Fibroblast growth factor homologous factors tune arrhythmogenic late NaV1.5 current in calmodulin binding-deficient channels. JCI Insight. 2020 Oct 2;5(19):e141736

  12. Chakouri N, Diaz J, Yang PS, Ben-Johny M. CaV channels reject signaling from a second CaM in eliciting Ca(2+)-dependent feedback regulation. J Biol Chem. 2020.

  13. Abrams JM, Roybal D, Chakouri N, Katchman AN, Weinberg RL, Yang L, Chen BX, Zakharov SI, Hennessey JA, Avula UMR, Diaz J, Wang C, Wan EY, Pitt GS, Ben-Johny M, Marx SO. Fibroblast growth factor homologous factors tune arrhythmogenic late NaV1.5 current in calmodulin-binding-deficient channels. JCI Insight. 2020.

  14. Zhang M, Kwon SE, Ben-Johny M, O'Connor DH, Issa JB. Spectral hallmark of auditory-tactile interactions in the mouse somatosensory cortex. Commun Biol. 2020;3(1):64.

  15. Liu G, Papa A, Katchman AN, Zakharov SI, Roybal D, Hennessey JA, Kushner J, Yang L, Chen BX, Kushnir A, Dangas K, Gygi SP, Pitt GS, Colecraft HM, Ben-Johny M, Kalocsay M, Marx SO. Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics. Nature. 2020;577(7792):695-700.

  16. Yoder JB, Ben-Johny M, Farinelli F, Srinivasan L, Shoemaker SR, Tomaselli GF, Gabelli SB, Amzel LM. Ca(2+)-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif. Nat Commun. 2019;10(1):1514.

  17. Niu J, Dick IE, Yang W, Bamgboye MA, Yue DT, Tomaselli G, Inoue T, Ben-Johny M. Allosteric regulators selectively prevent Ca(2+)-feedback of CaV and NaV channels. Elife. 2018;7.

  18. Niu J, Yang W, Yue DT, Inoue T, Ben-Johny M. Duplex signaling by CaM and Stac3 enhances CaV1.1 function and provides insights into congenital myopathy. J Gen Physiol. 2018;150(8):1145-61.

  19. Yellin F, Li Y, Sreenivasan VKA, Farrell B, Johny MB, Yue D, Sun SX. Electromechanics and Volume Dynamics in Nonexcitable Tissue Cells. Biophys J. 2018;114(9):2231-42.

  20. Gonzalez-Perez V, Ben Johny M, Xia XM, Lingle CJ. Regulatory gamma1 subunits defy symmetry in functional modulation of BK channels. Proc Natl Acad Sci U S A. 2018;115(40):9923-8.

  21. Banerjee R, Yoder JB, Yue DT, Amzel LM, Tomaselli GF, Gabelli SB, Ben-Johny M. Bilobal architecture is a requirement for calmodulin signaling to CaV1.3 channels. Proc Natl Acad Sci U S A. 2018;115(13):E3026-E35.

    ———— Before 2018 ————

  22. Chao YK, Schludi V, Chen CC, Butz E, Nguyen ONP, Muller M, Kruger J, Kammerbauer C, Ben-Johny M, Vollmar AM, Berking C, Biel M, Wahl-Schott CA, Grimm C. TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms. Proc Natl Acad Sci U S A. 2017;114(41):E8595-E602.

  23. Niu J, Ben Johny M, Dick IE, Inoue T. Following Optogenetic Dimerizers and Quantitative Prospects. Biophys J. 2016;111(6):1132-40. Epub 2016/08/21. doi: 10.1016/j.bpj.2016.07.040.

  24. Limpitikul WB, Dick IE, Ben-Johny M, Yue DT. An autism-associated mutation in CaV1.3 channels has opposing effects on voltage- and Ca(2+)-dependent regulation. Sci Rep. 2016;6:27235.

  25. Dick IE, Limpitikul WB, Niu J, Banerjee R, Issa JB, Ben-Johny M, Adams PJ, Kang PW, Lee SR, Sang L, Yang W, Babich J, Zhang M, Bazazzi H, Yue NC, Tomaselli GF. A rendezvous with the queen of ion channels: Three decades of ion channel research by David T Yue and his Calcium Signals Laboratory. Channels (Austin). 2016;10(1):20-32.

  26. Butz ES, Ben-Johny M, Shen M, Yang PS, Sang L, Biel M, Yue DT, Wahl-Schott C. Quantifying macromolecular interactions in living cells using FRET two-hybrid assays. Nat Protoc. 2016;11(12):2470-98.

  27. Ben-Johny M, Yue DN, Yue DT. Detecting stoichiometry of macromolecular complexes in live cells using FRET. Nat Commun. 2016;7:13709.

  28. Ben-Johny M, Dick IE, Sang L, Limpitikul WB, Kang PW, Niu J, Banerjee R, Yang W, Babich JS, Issa JB, Lee SR, Namkung H, Li J, Zhang M, Yang PS, Bazzazi H, Adams PJ, Joshi-Mukherjee R, Yue DN, Yue DT. Towards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium Channels. Curr Mol Pharmacol. 2015;8(2):188-205. Epub 2015/05/15.

  29. Yang PS, Ben-Johny M, Yue DT. Allostery in Ca(2)(+) channel modulation by calcium-binding proteins. Nat Chem Biol. 2014;10(3):231-8.

  30. Caraveo G, Auluck PK, Whitesell L, Chung CY, Baru V, Mosharov EV, Yan X, Ben-Johny M, Soste M, Picotti P, Kim H, Caldwell KA, Caldwell GA, Sulzer D, Yue DT, Lindquist S. Calcineurin determines toxic versus beneficial responses to alpha-synuclein. Proc Natl Acad Sci U S A. 2014;111(34):E3544-52.

  31. Ben-Johny M, Yue DT. Calmodulin regulation (calmodulation) of voltage-gated calcium channels. J Gen Physiol. 2014;143(6):679-92. Epub 2014/05/28. doi: 10.1085/jgp.201311153.

  32. Ben-Johny M, Yang PS, Niu J, Yang W, Joshi-Mukherjee R, Yue DT. Conservation of Ca2+/calmodulin regulation across Na and Ca2+ channels. Cell. 2014;157(7):1657-70.

  33. Adams PJ, Ben-Johny M, Dick IE, Inoue T, Yue DT. Apocalmodulin itself promotes ion channel opening and Ca(2+) regulation. Cell. 2014;159(3):608-22.

  34. Ben-Johny M, Yang PS, Bazzazi H, Yue DT. Dynamic switching of calmodulin interactions underlies Ca2+ regulation of CaV1.3 channels. Nat Commun. 2013;4:1717.

  35. Bazzazi H, Ben-Johny M, Adams PJ, Soong TW, Yue DT. Continuously tunable Ca(2+) regulation of RNA-edited CaV1.3 channels. Cell Rep. 2013;5(2):367-77.

  36. Tadross MR, Ben-Johny M, Yue DT. Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of Ca(v)1.3 channels. J Gen Physiol. 2010;135(3):197-215.

  37. Ariel M, Johny MB. Analysis of quantal size of voltage responses to retinal stimulation in the accessory optic system. Brain Res. 2007;1157:41-55.